The Skeoge road has reopened following a road traffic collision earlier on Monday morning.
One man has been taken to Altnagelvin Area Hospital with serious injuries.
Police in Derry continue to appeal to the public for any information regarding the incident.
Inspector McDermot said: “We received a report shortly after 12:35am that a male who was a back seat passenger in an red/orange-coloured Lexus IS 200 sport had sustained serious injuries.
“No other vehicles are reported to have been involved.
“Police and the Northern Ireland Ambulance Service attended the scene, and the man was taken to hospital where he remains this morning.
“As we continue with our enquiries, the carriageway between the Buncrana Road and Upper Galliagh Road remains closed.”
He added: “I want to appeal to anyone who was on the Skeoge Road prior to or around the time the collision was reported to us and who saw what happened or captured the incident on their Dash Cam to get in touch by calling us on the non emergency number 101, quoting reference 25 of 24/06/19.”