Lord Trimble, who died on Monday aged 77, led the Ulster Unionist Party (UUP) between 1995 and 2005.
He was instrumental in the negotiation of the 1998 Good Friday Agreement – the peace deal which ended the worst of the Troubles.
Lord Trimble won the Nobel Peace Prize, along with SDLP leader John Hume.
Since 2006, he sat in the House of Lords.
He was the first person to serve in the role of first minister in the new Northern Ireland Executive established as part of the Good Friday Agreement.
In a statement, President Clinton said he and his wife were “deeply saddened” by Lord Trimble’s death, saying his “lifetime of service helped bring peace to Northern Ireland”.
“Time after time during the negotiations that led to the Good Friday Agreement, he made the hard choices over the politically expedient ones because he believed future generations deserved to grow up free from violence and hatred.
“His faith in the democratic process allowed him to stand up to strong opposition in his own community, persuade them of the merits of compromise, and share power with his former adversaries. His legacy will endure in all who are living better lives because of him today.”
Current UUP leader Doug Beattie described Lord Trimble as a “political giant”.
“David Trimble was a man of courage and vision. He chose to grasp the opportunity for peace when it presented itself and sought to end the decades of violence that blighted his beloved Northern Ireland,” Mr Beattie said.
“He will forever be associated with the leadership he demonstrated in the negotiations that led up to the 1998 Belfast Agreement.
“The bravery and courage he demonstrated whilst battling his recent illness was typical of the qualities he showed in his political career, at Stormont and at Westminster.”
Prime Minister Boris Johnson described Lord Trimble as “a giant of British and international politics”.
“[He] will be long remembered for his intellect, personal bravery and fierce determination to change politics for the better,” Mr Johnson added.
Taoiseach Micheál Martin said Lord Trimble played “a crucial and courageous role in bringing peace to Northern Ireland”.
Sinn Féin vice-president Michelle O’Neill said Lord Trimble’s courage in helping negotiate the agreement “leaves a legacy a quarter century on for which he and his family should be rightly proud”.
DUP leader Sir Jeffrey Donaldson said the former first minister “made a huge contribution to Northern Ireland, and to political life in the United Kingdom” and was a “committed and passionate unionist who always wanted the best for Northern Ireland”.
Sir Jeffrey’s disagreements with Lord Trimble over the Good Friday Agreement led to him quitting the UUP in 2003 and defecting to the DUP.
“Whilst our political paths parted within the Ulster Unionist Party, there can be no doubting his bravery and determination in leadership at that time,” Sir Jeffrey added.
Lord Trimble’s political journey took him from a young hardliner in the 1970s to a unionist leader who compromised to help deliver an executive and assembly at Stormont where unionism and nationalism shared power.
He received much praise, including the Nobel Peace Prize with Mr Hume, for helping to bring to an end to decades of violence in Northern Ireland.
Mr Hume died in August 2020, a few months after Seamus Mallon of the SDLP, who served as deputy first minister when Lord Trimble was first minister.
Former Taoiseach Bertie Ahern, who led the Irish government at the Good Friday Agreement negotiations in 1998, said Lord Trimble was courageous and that although they had “many a row, many arguments”, they were able to laugh about that in later years.
“As a good negotiator, when he made a deal, when he settled something, he stuck by it,” Mr Ahern said.
“He stuck by it subsequently and he paid a price, he lost his seat in Upper Bann, he got a lot of criticism from his wider unionist family.
“He was a good guy and he stood firmly by what he believed in and I had a long chat with him just a few weeks ago in Queen’s [University] and he knew what was coming, he was brave in that, as he was in everything else.”
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