Jacqueline and Scarlett were last seen at around 2.30pm on Sunday, July 24, in the Shantallow area of the city.
Scarlet is described as having hazel-coloured eyes and light brown hair, which was tied up in a ponytail.
Jacqueline is described as 39-years-old, of slim build, approximately 5’10” tall with shoulder length dark brown, curly hair, green eyes and, when last seen, was wearing a red check shirt, blue jeans and carrying a red handbag.
Police believe Jacqueline and Scarlet may have travelled to the Republic of Ireland in a blue Ford Kuga with a green ‘Children On Board’ sticker.
Police are keen to know that Scarlet is safe and well, and are appealing directly to the person they believe Scarlet is with to get in touch.
Police are also appealing to anyone with information on the whereabouts of Jacqueline and Scarlet, to call 101, quoting reference 1076 of 24/07/22.