Mulrines is redeveloping 22 acres of the the former Herdman’s Mill site in Sion Mills.
The company will produce oat drink and fruit juice products at the new facility.
It said the jobs would pay average salaries in in the mid £20,000 range and would be in place by 2026.
Company chairman Peter Mulrine said the Sion Mills project was the culmination of a number of years of research, planning and negotiation.
He said the construction of the new factory was the first phase of the company’s investment in the village.
“The additional production capacity offers a significant opportunity for us to deliver additional fruit juice sales across our existing and new markets,” he said.
“As a result of increased production, we are likely to need additional storage which will form the basis of our second phase of investment in the facility.”
The new jobs are being supported by Invest NI.
Herdman’s Mill was built in 1835 by James George and John Herdman from Belfast.
It once employed more than 1,000 staff, ceased spinning linen in 2004 and the company that owned the mill went into receivership in 2011.
The site was bought by local lottery winner Margaret Loughrey for £1m in 2014.A fire broke out at the site in 2019.
The £27 million lottery died suddenly in September 2021 at a house in Strabane.
Her death was not treated as suspicious.
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